Information is stored in the cell both genetically and in the form of cellular structure. The spatial organization mediated by organelles and molecular machines is important for many biochemical reactions and processes. It allows the diversity of simultaneous reactions to occur in a controlled fashion with multiple layers of cross talk and regulation. As we move to a more comprehensive understanding of cellular processes, the spatial organization of their components becomes ever more important. This spatial component allows us to understand where processes initiate, how reactions are confined to the proper place and how they can be regulated differentially in the cell.
But cellular structures and organelles are not only mediators of compartmentalization of reactions, but they are themselves target of often complicated control mechanisms regulating their abundance and function according to need.
Our research focuses therefore on the spatial organization of biochemical reactions and the homeostatic control of cellular structures and organelles
We are currently investigating two areas in this field:
The regulation of plasma membrane homeostasis and the function of eisosomes. These are large immobile structures underneath the plasma membrane that mark sites of endocytosis. We are aiming to understand their molecular function, their biogenesis and their role in plasma membrane homeostasis.
Robert Farese's lab we are elucidating mechanisms of adiposome formation and dynamics.
Top
Print